Genetic incompatibility among influenza A viruses
Identifieur interne : 000181 ( Istex/Curation ); précédent : 000180; suivant : 000182Genetic incompatibility among influenza A viruses
Auteurs : Masato Hatta [États-Unis] ; Peter Halfmann [États-Unis] ; Krisna Wells [États-Unis] ; Yoshihiro Kawaoka [Japon, États-Unis]Source :
- International congress series [ 0531-5131 ] ; 2001.
English descriptors
- Teeft :
- Avian, Avian influenza, Avian viruses, Cdna, Elsevier science, Genetic basis, Genetics, Genetics system, Host range restriction, Human influenza, Human strains, Human virus replication, Influenza, International congress series, Kawaoka, Luenza, Luenza viruses, Medical science, Other genes, Reassortant, Reassortant viruses, Replication, Tokyo japan, Various combinations.
Abstract
Abstract: Although influenza A viruses occasionally transmit from one species to another, host range restriction exists among these viruses. Current human influenza A viruses are thought to originate from avian viruses. However, human influenza A viruses do not replicate in duck intestine, a major replication site of avian viruses. Although previous studies identified that the HA and NA genes restrict human virus replication in ducks, the contribution of the other genes remains unknown. To determine the genetic basis for host range restriction in ducks, we first established a reverse genetics system for generating A/Memphis/8/88 (H3N2) and A/Mallard/NY/6750/78 (H2N2) viruses from cloned cDNA. Using this system, we attempted to generate reassortant viruses with various combinations of genes. However, reassortant viruses with some of the gene combinations were not generated, suggesting that there may be incompatibility between the genes of avian and human strains.
Url:
DOI: 10.1016/S0531-5131(01)00400-9
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Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato, Tokyo 108-8639, Japan. 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Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato, Tokyo 108-8639, Japan. 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Current human influenza A viruses are thought to originate from avian viruses. However, human influenza A viruses do not replicate in duck intestine, a major replication site of avian viruses. Although previous studies identified that the HA and NA genes restrict human virus replication in ducks, the contribution of the other genes remains unknown. To determine the genetic basis for host range restriction in ducks, we first established a reverse genetics system for generating A/Memphis/8/88 (H3N2) and A/Mallard/NY/6750/78 (H2N2) viruses from cloned cDNA. Using this system, we attempted to generate reassortant viruses with various combinations of genes. However, reassortant viruses with some of the gene combinations were not generated, suggesting that there may be incompatibility between the genes of avian and human strains.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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